WebAutophagic degradation of IRF3 induced by the small-molecule auranofin inhibits its transcriptional and proapoptotic activities Autophagic degradation of IRF3 induced by the small-molecule auranofin inhibits its transcriptional and proapoptotic activities J Biol Chem. 2024 Oct 5;297 (5):101274. doi: 10.1016/j.jbc.2024.101274. Online ahead of print. WebIRF3 → Interferon regulatory factor 3 (IRF-3) Gene name : IRF3 Family name : IRF Entry whose protein (s) existence is based on evidence at protein level. Show evidences Annotations in this section apply to all the isoforms if not specified otherwise. OVERVIEW
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WebHowever, the mechanisms by which IRF3 causes ALD remain obscure.IRF3 is a constitutively expressed transcription factor that resides in the cytoplasm and dimerizes … WebSince STAT2 inhibits the transcription of IRF3-dependent, but not NF-kB–dependent genes, STAT2 may impair the ability of TBK1 to phosphorylate IRF3 by disrupting the IRF3–STING interaction. On the other hand, STAT2 has a strong nuclear export signal when Y690 is not phosphorylated ( 50 ).
WebJul 25, 2024 · The discovery Interferon-regulatory factor 3 (IRF3) and IRF7 are the two pivotal transcriptional factors that directly control the production of IFN-α and IFN-β, determining the antiviral... WebJan 8, 2024 · The mammalian IRF family proteins are structurally related transcription factors consisting of nine members: IRF1, IRF2, IRF3, IRF4 (also called ICSAT [IFN consensus sequence-binding protein for activated T-cells], LSIRF [lymphocyte-specific IRF], PIP [PU.1-interacting protein]), IRF5, IRF6, IRF7, IRF8 (also referred to ICSBP [IFN …
WebApr 11, 2024 · TLR signaling cascades typically converge on transcription factors such as NFκB, AP-1, and IRF3 that initiate the synthesis of a battery of innate immune effectors involved in antibacterial ... WebIRF3 is a transcription factor that controls multiple IFN-inducing pathways, including the TLR3 pathway, which can be triggered by dsRNA, and the pathways triggered by other …
WebIRF3 is a transcription factor which is a major regulator of the type I interferon (IFN) antiviral response after recognition of viral DNA or RNA by intracellular foreign nucleic acid sensors, such as Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I), and cyclic GMP-AMP synthase (cGAS) (reviewed in [10]). IRF3 activa-
WebMay 31, 2024 · IRF3 (interferon regulatory factor 3) is one of the most critical transcription factors in antiviral innate immune signaling, which is ubiquitously expressed in a variety of cells. earl biss serigraphs for saleWebMar 29, 2024 · IRF3 is activated by phosphorylation (by kinases TBK1 and IKKε), promoting dimerization, nuclear translocation, association with the co-activator CREB-binding protein … earl blackman obituaryWebOct 15, 2024 · Using two model transcription factors, IRF3 and STAT1, we demonstrate that transcription factor dimerization enables the trans-autoacetylation of p300 in a highly … earl biss war partyWebMay 27, 2024 · Thereafter, TBK1 in this signalosome phosphorylates C-terminus of interferon regulatory factors 3 (IRF3), which mobilizes IRF3 for dimerization and nuclear translocation, where it functions as transcription factor to induce the expressions of type I interferons (IFN-Is), various cytokines, and subsequently a multitude of IFN-stimulated … earl biss wikiIRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association … See more Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. See more IRF3 has been shown to interact with IRF7. See more • Pitha PM, Au WC, Lowther W, Juang YT, Schafer SL, Burysek L, Hiscott J, Moore PA (1999). "Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth" See more • Interferon+Regulatory+Factor-3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook IRF3 See more css first selectorWebMar 9, 2024 · IRF3 is a major transcriptional regulator of adipose inflammation and is involved in maintaining systemic glucose and energy homeostasis Findings indicate that STING-TBK1-IRF3 pathway mediates a crosstalk between ER stress and apoptosis during M. bovis infection, which can effectively control intracellular bacteria. earl blackmon cpaWebThe infection of mammalian cells by viruses and innate immune responses to infection are spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation of the transcription factor interferon regulatory factor 3 (IRF3) and consequent induction of host immune responses to RNA viruses. earl bistro